Chris Bosh scored 17 points and LeBron James scored 13 for Miami, which led 27-11 after one quarter in its first exhibition since returning home from China earlier this week.
Combined, the Wade-Bosh-James trio shot 19 for 31 from the floor, with 14 assists and 13 rebounds.
Greg Monroe scored 15 points for Detroit, which missed 18 of its first 22 shots. Brandon Knight added 12 for the Pistons.
Detroit lost veteran Corey Maggette in the first half with a strained left calf. Maggette pulled up after only 2 minutes and did not return.
Source: Associated Press