It was the 10th 30-point game of the season for James. The Heat are 9-1 when he scores that many.
Chris Andersen was 7 for 7 from the field and scored 15 points, and Chris Bosh added 12 points and nine rebounds for the Heat, who trailed by 11 points early in the third quarter.
Miami then outscored New Orleans 59-26 over the next 20 minutes, that run ending when James, Wade and Bosh departed for the night with about 3 minutes left.
Anthony Davis led the Pelicans with 22 points and 12 rebounds, Eric Gordon scored 15, and Tyreke Evans added 13 for New Orleans.
Source: Associated Press