George made four 3-pointers to get the best of his matchup with LeBron James. David West added 14 points and 11 rebounds, and Lance Stephenson chipped in with 13 points for the Pacers (21-14), who have won 11 of their last 14 games.
Dwyane Wade scored 30 points and James had 22 points and 10 rebounds for Miami (23-10), which still has the best record in the Eastern Conference.
It was the first time the teams had met since Miami beat the Pacers in six games in the conference semifinals last year.
The Pacers outrebounded the Heat 55-36 to help make up for 36 percent shooting.
Source: Associated Press