Veteran quarterback Kevin Kolb, who is competing with Manuel for the starting job, dressed but served as the emergency quarterback in the preseason opener after missing most of the week of practice.
Manuel did not throw an interception, but was credited with a fumble on a botched hand-off to running back C.J. Spiller that was recovered by the Colts.
However, Manuel led the Bills on a 95-yard drive with less than two minutes left in the first half, going 9-for-9 passing. Manuel’s 17-yard touchdown pass to tight end Dorin Dickerson to cap the drive gave the Bills a 20-13 lead going into the second half.
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