Guthrie neatly handled a nemesis and a 59-minute delay to pitch into the seventh inning, Billy Butler homered and the Kansas City Royals held on to beat New York 5-1 Monday night.
Guthrie (8-6) gave up three hits over six innings, albeit to a Yankees lineup that had only four players that were with the team on opening day.
Leading 5-1, closer Greg Holland was needed in the ninth when Lyle Overbay walked and Luis Cruz singled to start the inning against Luke Hochevar. Holland gave up a hit to Chris Stewart to load the bases. But Holland struck out Eduardo Nunez, Brett Gardner and Zoilo Almonte to end it for his 21st save.
Guthrie twice struck out the newest member in pinstripes, Travis Ishikawa, before Overbay homered pinch hitting for the first baseman who was claimed off waivers from Baltimore on Sunday. Overbay’s 10th of the year was New York’s first long ball in six games.